论文目录 | |
| Abstract | 第1-6页 |
| 摘要 | 第6-7页 |
| Main novelties | 第7-10页 |
| Chapter 1 Introduction | 第10-63页 |
| 1.1 Chirality and Asymmetric Synthesis | 第10-16页 |
| 1.1.1 Chiral pool synthesis | 第11-12页 |
| 1.1.2 Chiral auxiliaries | 第12页 |
| 1.1.3 Chiral reagents | 第12-13页 |
| 1.1.4 Chiral catalysts | 第13-16页 |
| 1.2 Oxindoles-Biologically active compounds | 第16-19页 |
| 1.3 Oxindoles-Asymmetric synthesis | 第19-61页 |
| 1.3.1 Asymmetric synthesis of 3,3'-disubstituted oxindoles | 第19-40页 |
| 1.3.2 Asymmetric construction of 3,3'-spirocyclic oxindoles | 第40-61页 |
| 1.4 Conclusion and Objectives of This Study | 第61-63页 |
| Chapter 2 Enantio- and Diastereoselective Synthesis of Spiro-epoxyoxindoles | 第63-102页 |
| 2.1 Introduction | 第63-72页 |
| 2.2 Results and Discussion | 第72-81页 |
| 2.2.1 Synthesis of Starting Materials | 第72-73页 |
| 2.2.2 Optimization of Reaction Conditions | 第73-77页 |
| 2.2.3 Investigation of the Substrate Scope | 第77-79页 |
| 2.2.4 Proposed Mechanistic Aspects and Mode of Asymmetric Induction | 第79-81页 |
| 2.3 Conclusion | 第81-82页 |
| 2.4. Experimental Procedure | 第82-102页 |
| 2.4.1 Material and General Methods | 第82页 |
| 2.4.2 Synthesis of Starting Materials | 第82-84页 |
| 2.4.3 Synthesis and Characterization of Products | 第84-89页 |
| 2.4.4 Crystal Data of X-Ray Crystallographic Analysis and Determination of Configurationof the spiro-epoxyoxindole Ⅱ-41ka | 第89-102页 |
| Chapter 3 Catalytic Asymmetric Allylation of 3-Aryloxindoles by Merging Palladium Catalysisand Asymmetric H-bonding Catalysis | 第102-135页 |
| 3.1 Introduction | 第102-108页 |
| 3.2 Results and Discussion | 第108-123页 |
| 3.2.1 Synthesis of Starting Materials | 第108-110页 |
| 3.2.2 Optimization of Reaction Conditions | 第110-117页 |
| 3.2.3 Investigation of the Substrate Scope | 第117-121页 |
| 3.2.4 Determination of Absolute Configuration of the Product and Possible Mechanism | 第121-123页 |
| 3.3 Conclusion | 第123页 |
| 3.4 Experimental Procedure | 第123-135页 |
| 3.4.1 Material and General Methods | 第123-124页 |
| 3.4.2 Synthesis of Starting Materials | 第124-127页 |
| 3.4.3 Synthesis and Characterization of Products | 第127-135页 |
| Chapter 4 Summary | 第135-137页 |
| References | 第137-165页 |
| Appendix Ⅰ: spectra of typical compounds | 第165-198页 |
| Publications | 第198-199页 |
| Acknowledgements | 第199-200页 |
