论文目录 | |
| 摘要 | 第1-6页 |
| ABSTRACT | 第6-13页 |
| Chapter 1 Introduction | 第13-48页 |
| 1.1 Advantages of transition metal free protocol | 第13-16页 |
| 1.1.1 Transition metal free green chemistry approach | 第13页 |
| 1.1.2 Advantages of Transition-Metal-Free synthesis | 第13-15页 |
| 1.1.3 Need of TMF protocol | 第15页 |
| 1.1.4 Limitation of transition metal catalysis | 第15-16页 |
| 1.2 Indole an overview | 第16-23页 |
| 1.2.1 Introduction to indole | 第16-17页 |
| 1.2.2 Indoles in natural products | 第17-18页 |
| 1.2.3 Biological and medicinal importance of indole | 第18-21页 |
| 1.2.4 Indole ring containing important marketed drugs molecules | 第21-23页 |
| 1.3 Review on indole synthesis from aromatic amino alcohol | 第23-34页 |
| 1.3.1 Homogeneous Catalysis | 第24-29页 |
| 1.3.2 Heterogeneous catalyzation of amino alcohols to indole | 第29-34页 |
| 1.3.3 Production of indole in water | 第34页 |
| 1.4 Review of amino alcohol to indole (a critical analysis) | 第34-37页 |
| 1.4.1 Homogeneous catalysis | 第35页 |
| 1.4.2 Heterogeneous catalysis | 第35-37页 |
| 1.5 Transition metal-free synthesis of indole | 第37-40页 |
| 1.5.1 Fischer indole synthesis | 第38-39页 |
| 1.5.2 Metal free indole synthesis using DDQ as oxidant | 第39-40页 |
| 1.5.3 Metal free Se-catalyzed indole synthesis | 第40页 |
| 1.6 Motivation and Thesis outline | 第40-42页 |
| 1.7 References | 第42-48页 |
| Chapter 2. Synthesis and Characterization of Indole | 第48-86页 |
| 2.1 Introduction to TMF, base promoted, aerobicoxidative cyclization of indole | 第48-49页 |
| 2.2 Results and discussions | 第49-58页 |
| 2.2.1 Optimization of reaction conditions | 第49-54页 |
| 2.2.2 Scope of reaction | 第54-58页 |
| 2.3 Experimental Section | 第58-61页 |
| 2.3.1 Materials | 第58页 |
| 2.3.2 Analytical Methods | 第58-59页 |
| 2.3.3 Experimental Methods for amino alcohol preparation | 第59-61页 |
| 2.4 Applications of the protocol | 第61-64页 |
| 2.4.1 Gram scale Total synthesis of Potent anti-breast-cancer drug (2-31) | 第61-62页 |
| 2.4.2 Experimental procedure for suzuki cross coupling reaction | 第62-64页 |
| 2.5 Characterization | 第64-83页 |
| 2.5.1 Characterization of amino alcohols | 第64-73页 |
| 2.5.2 Characterization of 2-substituted aliphatic amino alcohols | 第73-74页 |
| 2.5.3 Characterization of indole (NMR Spectra) | 第74-83页 |
| 2.6 References | 第83-86页 |
| Chapter 3. Aerobic oxidative Synthesis of Benzophenone viaWittig Reagent | 第86-94页 |
| 3.1 Introduction to ketone synthesis via Wittig intermediate | 第86-87页 |
| 3.1.1 Background | 第86-87页 |
| 3.1.2 One-pot Synthesis of Benzophenone via Wittig Intermediate | 第87页 |
| 3.2 Result and discussion | 第87-90页 |
| 3.2.1 Optimization of reaction condition | 第87-90页 |
| 3.3 Control reactions for understanding the pathway mechanism and ofketone synthesis | 第90-92页 |
| 3.3.1 Experimental verification for understanding the pathway of ketonesynthesis | 第90-91页 |
| 3.3.2 Control reactions for understanding the addition of Base after ylideformation | 第91-92页 |
| 3.4 Possible Mechanism | 第92页 |
| 3.5 Conclusion | 第92-93页 |
| 3.6 References | 第93-94页 |
| NMR Specta of Compounds | 第94-120页 |
| Acknowledgements | 第120-121页 |
| List of Publications | 第121页 |
