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HG颗粒对四氯化碳复合法致肝纤维化大鼠肝胶原纤维及羟脯氨酸含量的影响 |
[生化制药论文]
作者:毕红征,薛敬礼,黄国钧,王纯耀
【摘要】 目的研究HG颗粒对(四氯化碳)CCl4 致肝纤维化大鼠肝脏胶原纤维及羟脯氨酸(Hyb)含量的影响。方法70只SD大鼠,除空白对照组10只外,其余各组大鼠皮下注射CCl4,同时予高脂饲料和20%乙醇喂养6周建立肝纤维化大鼠模型,存活大鼠随机分为5组,加上空白对照组,动物共计6组,分别给予药物或蒸馏水。空白对照组:蒸馏水0.1 ml/kg;模型对照组:蒸馏水0.1 ml/kg;HG颗粒高,中,低3种剂量组:6,3,1.5 g生药/kg;复方鳖甲软肝片组:1 g/kg,灌胃治疗,1次/d,连续4周。观察大鼠肝胶原纤维及Hyb含量的变化。结果模型大鼠肝胶原纤维及Hyb含量均明显增高。HG颗粒3剂量组治疗后均能降低大鼠肝胶原纤维组织及Hyb含量,复方鳖甲软肝片亦可降低胶原纤维及Hyb含量。结论 HG颗粒对CCl4复合法致肝纤维化模型大鼠具有显著的治疗作用。
【关键词】 HG颗粒;胶原纤维;羟脯氨酸
Abstract:ObjectiveTo explore the effects of HG Granule on collagen and Hyp in the liver of HF model rats. MethodsSeventy SD rats excluding ten rats in blank control group were injected carbon tetrar-chloride(CCl4) hypodermicly,at the same, fed with the high fat and 20% ethyl alcohol for six weeks to established HF model rats. Existing rats were divided into five groups randomly acconding to sex and weight. All rats were given drugs or distilled water.Blank control group: distilled water 0.1ml/kg;mo……
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生化制药论文 | 生化制药论文 |
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