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抗丙型肝炎病毒第一高变区抗体捕获HCV病毒的实验研究 |
[高血压医学论文] 【摘要】 目的 采用抗丙型肝炎病毒(HCV)第一高变区(HVR1)抗体,建立病毒捕获实验。方法 重组表达HVR1嵌合抗原,免疫家兔,制备抗HVR1抗体,与20例患者阳性血清反应,通过HCV RT-PCR检测捕获结果。结果 在30例样品中有13例完全捕获,16例部分捕获 ,仅1例未捕获。结论 抗HVR1多抗可高交叉捕获HCV病毒。 【关键词】 肝炎病毒丙型; 互补决定区抗体; 聚合酶链反应 Studies on the antibodies against hypervariable 1(HVR1) of hepatitis C virus (HCV) capture virus 【Abstract】 Objective A set of test capture virus was formulated. Using antibodies against hypervariable 1(HVR1) of hepatitis C virus (HCV). Methods Recombinant expression antigens of chimeric HVR1, the preparation of antibodies against HVR1 by immuno-rabbit,with 30 cases patients of HCV infection capture test,the results were detected by HCV RT-PCR. Results In 30 cases of HCV infection can capture virus of 13cases completely, 16 cases capture partly,only 1case can not capture. Conclusions The antibodies against hypervariable 1(HVR1) of hepatitis C virus (HCV) can broadly capture virus of HCV. 【Key words】 hepatitis C virus; complementarity determining regions antibody; polymerase chain reaction 丙型肝炎是由丙型肝炎病毒(HCV)感染引起的世界性传染病。研究表明,约70%~85%的HCV感染将发展为……
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投稿人:gf6h6 |
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最后编辑:647754 |
高血压医学论文 | 高血压医学论文 |
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