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血β2－微球蛋白在血友病合并艾滋病和丙型肝炎高效抗逆转录病毒治疗疗效判断中的作用 |
| [高血压医学论文] 【摘要】 目的 了解血β2－微球蛋白（血β2－MG）在AIDS高效抗逆转录病毒治疗（HAART）疗效判断中的作用。方法 收集血友病合并艾滋病和丙型肝炎患者25例接受HAART 1年。治疗前及治疗开始后第1、3、6、9、12个月底检测CD4+细胞计数、HIV-RNA载量和血β2－MG。对治疗前后的数据进行配对分析和相关性分析。结果 治疗第1、3、6、9、12个月时CD4+细胞计数较治疗前有显著上升，HIV-RNA载量较治疗前有显著下降。治疗第3、9、12个月时血β2－MG较治疗前亦有显著下降。血β2－MG与CD4+细胞计数、血β2－MG与HIV-RNA载量之间没有很好的相关性。结论 血β2－MG在HAART疗效判断中有一定的监测作用。 【关键词】 血β2－MG；CD4+细胞计数；HIV-RNA载量；HAART The role of serum β2-microglobulin in monitoring the efficiency of HAART in 25 AIDS patients 【Abstract】 Objective To know the role of serum β2-microglobulin（serumβ2－MG）in monitoring the efficiency of high active anti-retroviral therapy（HAART）in AIDS patients.Methods 25 AIDS patients with HCV（+） were treated with HAART for 1 year and their serumβ2－MG，CD4+ cell counts and HIV-RNA were measured before initiation of treatment and at the 1st，3rd，6th，9th and12th month of treatment.The data was analyzed with pared-samples test and correlation test.Results CD4+ cell counts were significantly increased and HIV-RNA decreased at the 1st，3rd，6th，9th and12th month of treatment while serum β2－MG were significantly decreased at the 3rd，9th and12th month of treatment.Serum β2－MG do not……
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| 投稿人：gf6h6 |
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最后编辑：647754 |
高血压医学论文 | 高血压医学论文 |
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