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分泌型单链双功能抗体分子间接头的设计及软件分析 |
[高血压医学论文] 【关键词】 抗体,双特异性;肿瘤坏死因子类;计算生物学
Design and analysis of linkers among secretary singlechain bifunctional antibody fusion molecules with bioinformatics software
【Abstract】 AIM: AIM: To analyze the secondary structure and the physical and chemical characteristics of the secretary antiosteosarcoma singlechain bifunctional antibody fusion protein with bioinformatics software. METHODS: The sites of enzyme were selected for the sequence of linker. Bioinformatics software was used to analyze structural change of the singlechain antibody fragments of variable domaintumor necrosis factor (ScFvTNF) fusion protein, and then DNAssist and ANTHEPROT V5 were used to analyze its sequence, secondary structure, and physical and chemical characteristics. RESULTS: On the fusion genes, the sites of enzyme were selected for the sequence of linker, and the secondary structure of the fusion protein was obtained with DNAssist, and the physical and chemical characteristics of the fusion protein were forecasted with ANTHEPROT V5. CONCLUSION: The software for bioinformatics should be fully utilized to analyze biological information, and be improved continuously. Bioinformatics can shorten the course of pharmaceutical development, at the same time can help us to explore the genebased medicine. 【Keywords】 antibodies, bispecific; tumor necrosis factors; computational biology
【摘要】 目的: 利用生物信息学软件分析分泌型抗骨肉瘤单链双功能抗体融合蛋白的二级结构及其理化性质. 方法: 构建融合蛋白时,先进行连接肽的设计,选用通用酶切位……
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投稿人:gf6h6 |
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最后编辑:647754 |
高血压医学论文 | 高血压医学论文 |
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