【摘要】 目的观察胃肠舒片对胃肠运动的影响及毒副作用。方法胃肠舒片对胃肠推进运动实验，将动物随机分组，对比观察分析；对动物离体平滑肌的影响，采用给药前后对比观察分析；急性毒性实验将动物随机分组，对比观察；给予不同浓度胃肠舒片溶液灌胃，实验数据进行统计学处理（t检验）。结果胃肠舒片对胃肠运动有明显的推进作用，其机理与增强胃肠平滑肌自发活动的收缩幅度有关；口服给药安全，无明显毒副作用。结论 胃肠舒片是理想的纯中药制剂的胃肠动力药。
【关键词】 胃肠舒片 吗丁啉 胃肠平滑肌 药理作用 毒理学
The Pharmacological and Toxicological Experimenal Research of Weichangshu Tablet
Abstract:ObjectiveTo observe Weichangshu Tablet's effect on gastroentero-movement and the toxic side effect. Methods The experiment of Weichangshu Tablet's effect on gastroentero-propelling movement was done by dividing the animals into groups at random,observing and analyzing contrastively. The experiment of WeichAngshu Tablet's effect on animal unorganized ileum leiomyo was done by observing and analyzing between before medicine and after medicine. The acute toxicity experiment was done by dividing the animals into groups at random in which the animals were given different concentration solution of Weichangshu Tablet by way of gastric perfusion.ResultsWeichangshu Tablet promoted gastroentero-movement.Its mechanism is related to its building up the contractive range of the spontaneous activity of gastroentero-Leiomyo. Oral taking medicine is safe,and there is no evident toxicity side effect.ConclusionWeichangshu Tablet is a kind ……
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