| [高血压医学论文]
作者;白咸勇，贾秀红，刘同慎，李笑岩
【摘要】 目的 探讨碱性成纤维细胞生长因子(basic fibroblast growth factor，bFGF)在肝癌发生过程中的表达及意义。 方法 采用免疫组织化学ABC法对二乙基亚硝胺(DEN)诱发大鼠肝癌发生过程中碱性成纤维细胞生长因子表达情况进行观察。结果 DEN诱发大鼠肝癌发生率为100%。正常大鼠肝细胞bFGF表达为阴性，于诱癌第8周，肝小叶近门管区血管附近的少量肝细胞呈bFGF阳性表达，并可见门管区血管内皮细胞和成纤维细胞也呈bFGF阳性表达，随着诱癌进程的 发展 ，bFGF阳性肝细胞的数量逐渐增多，至诱癌第18周，癌结节内大部分肝癌细胞均呈bFGF阳性表达。结论 bFGF与肝癌的发生和发展具有相关性。
【关键词】 bFGF；大鼠；肝癌发生；免疫组织化学
The expression and significance of basic fibroblast growth factor(bfGF) during hepatocarcinogenesis in the rats
【Abstract】 Objective To investigate the expression and significance of basophilic fibroblast growth factor during hepatocarcinigenesis in the rats.Methods Hepatoma was induced in the rats by administration of diethylnitrosamine (DEN)，the expression of basic fibroblast growth factor (bFGF) was detected with immunohistochemical technique.Results The incidence of hepatocarcinogenesis induced by DEN was 100%，the expression of bFGF was not detected in hepatocytes of normal rats，a few of bFGF positive hepatocytes were detected near the fibr……
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