作者：张雷，浦奎，张素炎，任文琦

【关键词】  冠状动脉疾病

    Family history of coronary heart disease as an important predictor for nonalcoholic fatty liver disease

　　【Abstract】 AIM: To explore the relationship between family history of coronary heart disease (CHD), hypertension, and diabetes with nonalcoholic fatty liver disease (NAFLD). METHODS: Two hundred and two healthy office workers with no evidence of excessive alcohol drinking or hepatitis B or C virus infection were enrolled in the present study performed from March to June in 2004, and underwent liver ultrasound examination for diagnosing NAFLD. RESULTS: NAFLD was identified in 68 subjects (33.7%) by abdominal ultrasound. Logistic regression analysis showed that the presence of CHD family history increased the risk of NAFLD by 2.25fold (P=0.014), while family history of diabetes or hypertension did not increased the risk. In combination with the presence of a family history of CHD, the effect on odds ratios (ORs) was increased for several metabolic features in predicting the incidence of NAFLD, including increased waist circumference (OR=3.548, 95%CI: 1.895-6.643, P<0.001 vs OR=3.512, 95%CI: 1.831-6.737, P<0.001), hypertriglyceridemia (OR=4.549, 95%CI: 2.380-8.695, P<0.001 ……