作者：王银环，董淑云，张娜，赵利军，李宏杰，孔小燕，刘丽华，张连元

【关键词】  再灌注损伤；肝功能；四肢；牛磺酸

　　Protective effect of taurine against liver injury after limb ischemiareperfusion in rats

　　【Abstract】 AIM: To observe the liver injury and investigate the protective  effect of taurine on the liver function after limb ischemiareperfusion.  METHODS: Thirty Wistar rats were randomly divided into control group，ischemiareperfusion(IR) group and taurine + ischemiareperfusion (TR) group (n=10 per group). The values of XOD, LDH, MDA, AST, ALT and SOD in plasma were respectively measured after 4 h limb ischemia  and 4 h reperfusion  in each group. XOD, MDA, ROS, MPO and ［Ca2+］ in the liver tissues and GSHPX, ［Ca2+］ in the liver mitochondria were observed. RESULTS:  In IR group compared with the control group, the values of LDH ［(190.16±13.36) μkat/L vs (122.39±14.87) μkat/L］, XOD ［(758.82±151.53)  nkat/L vs (543.61±43.51) nkat/L］, MDA ［(5.19±0.67) nmol/L vs  (1.27±0.21) nmol/L］ , ALT ［(78.40±6.45) nkat/L vs  (20.50±3.70)  nkat/L］, AST ［(47.70±4.47) nkat/L vs (25.25±2.98) nkat/L］  in plasma increased, but SOD ［(1.30±0.15) μkat/L vs (1.80±0.16) μkat/L ］  reduced, XOD ［(104.69±12.34) μkat/kg vs (59.01±10.50) μkat/kg］, MDA ［(2.66±0.08) nmol/L vs (1.29±0.14) nmol/L］, ROS ［(771.65±100.69) μkat/L vs (606.45±52.01) μkat/L］, MPO (0.47±0.04 vs 0.28±0.06), ［Ca2+］……