| [高血压医学论文]
作者：刘玉珍，韩景献，蒋戈利，丁晓荣，陆明霞
【关键词】 针刺；,,脑缺血/再灌注；,,P
摘要：目的探讨针刺抗脑缺血再灌注炎性损伤的机理。 方法 采用线栓法制作大鼠大脑中动脉缺血模型（MCAO），采用免疫组织化学技术测定P-选择素和E-选择素表达的动态变化。结果在灌注3 h各实验组P选择素和E选择素均开始表达，二者均于再灌注24 h均达到高峰（组内比较P＜0.01），持续至再灌注48 h，针刺可显著降低P-选择素和E-选择素的表达（与模型组和非穴组比较，P＜0.01 ）。结论P选择素和E选择素的表达上调与再灌注后的炎症反应有关，早期针刺 治疗 可能通过下调脑缺血区黏附分子P选择素和E选择素的表达而防治脑缺血再灌注炎性损伤。
关键词：针刺； 脑缺血/再灌注； P选择素； E选择素
Effect of Galvano-acupuncture on the Expression of P-selectin and E-selectin of Cerebral Ischenic Region in Rats
Abstract：ObjectiveTo study mechanisms of early treatment of cerebral ischemia-reperfusion(I/R) by galvano-acupuncture in resisting inflammation injury in rats.MethodsCerebral I/R model was established by occlusion of the middle cerebral artery for 1h and then removal of the occlusion for 3 h ,12 h,24 h, and 48 h respectively . The expression of P-selectin and Eselectin was displayed by using imunohistochemical ABC in ischemic cerebral cortex and corpus striatum in rats.ResultsThe expression of P-selectin and Eselectin was detected at capillary walls in postischemic cerbral cortex at 1 h ischemia-3 h reperfusion and peaked at 1h ischemia-24 h reperf……
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