[高血压医学论文] 【关键词】 药物洗脱支架;,,超敏C反应蛋白质;,,白细胞介素-6
摘要:目的:比较药物洗脱支架与普通支架植入前后冠心病患者血超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、P选择素(P-selectin)、可溶性细胞间粘附分子(sICAM-1)的变化,探讨其意义。方法:选择有支架植入指征的冠心病患者66例,随机分为药物支架组和普通支架组,30例置入Cypher(Cypher支架组),36例置入普通Bxsonic支架(普通支架组)。分别于手术前,术后即刻,术后6h、术后24h、7d取肘静脉血, 采用ELISA法检测IL-6、P选择素、slCAM-1 、hs-CRP。结果:Cypher支架组与普通支架组比较P选择素、IL-6、sICAM-1、 hs-CRP水平在扩张前、术后即刻没有显著性差异(P>0.05)而术后6h、24h、7d时Cypher支架与普通支架比较测定值低且差异有显著性(P<0.05~0.01)。结论:Cypher药物洗脱支架对冠心病患者介入术后血炎症因子的产生有抑制作用,可能抑制介入术后的炎症反应是其抗再狭窄的机制之一。
关键词: 药物洗脱支架; 超敏C反应蛋白质; 白细胞介素-6
The Effects of Drug Eluting Stents on Level of Inflammatory Factors in Patients with CHD after Angioplasty
Abstract: Objective: To compare the effects of drug eluting stent versus common stent on the levels of serum high sensitive C-reactive protein(hs-CRP), interleukin-6(IL-6),plasma P-selectin and soluble intercellular adhesion molecule-I (sICAM-1) in patients with coronary heart disease before and after angioplasty. Method: 66 patients had been done coronary angiograph and divided randomizely into drug-eluting stents implantment group(30 cases of Cypher stent implantment) and common stents implantment group(36 cases of comm……
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