[高血压医学论文] 作者:李兰芳, 张勤增, 解丽君, 杨凤旭
【关键词】 通脉活血灵胶囊;,,大黄酚;,,血药浓度;,,HPLC
摘要:目的:观察大鼠口服通脉活血灵胶囊后,其效能成分大黄酚在大鼠体内的药动学过程。方法:大鼠单次灌服通脉活血灵胶囊,用反相高效液相法测定不同时间的血药浓度,采用DAS2.0药动学软件拟合处理该药的药动学参数。结果:通脉活血灵胶囊中大黄酚在大鼠体内的药动学参数:T1/2α,T1/2β,AUC(o-∞),K10,K12,K21,Tmax,Cmax分别为:1.054h,4.197h,2479.555 mg/L,0.077 1/h,0.222 1/h,0.407 1/h,0.5h,230.58 mg/L。结论:单次灌服通脉活血灵胶囊后,大黄酚在大鼠体内的药动学过程符合开放型二室模型,吸收快,消除慢,同服用单味大黄后大黄酚在家兔体内的药动学过程有一定的差异。
关键词: 通脉活血灵胶囊; 大黄酚; 血药浓度; HPLC
Determination of chrysophanol from Tongmaihuoxueling Capsules in rat’s plasma and study on its pharmacokinetics
Abstract: Objective: To study the pharmacokinetics of chrysophanol in rats after ig administration of Tongmaihuoxueling capsules(TC). Methods: The concentrations of chrysophanol in plasma were determined by RP-HPLC method after single ig administration of TC. The parameters of pharmacokinetics were computed by DAS 2.0 program. Results: The pharmacokinetic parameters of chrysophanol from TC in rats were as follows: T1/2α,T1/2β,AUC(o-∞),K10,K12,K21,Tmax,Cmax; Their value were respectively 1.054h,4.197h,2479.555 mg/L,0.07……
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