[高血压医学论文] 【关键词】 ,,冠心病
摘 要:目的:探讨通心络胶囊对冠脉内支架置入术后患者体内凝血―纤溶系统和血管紧张素Ⅱ的影响及其作用机制。方法:58例冠脉内支架置入术后患者随机分为两组:分别用常规药物(对照组29例)和常规药物加通心络胶囊(治疗组29例)治疗,观察对术后患者凝血―纤溶相关指标:组织型纤溶酶原激活物(t-PA)、纤溶酶原活化剂抑制物1(PAI-1)、抗凝血酶Ⅲ(AT-Ⅲ)、纤维蛋白原(FIB) 和血管紧张素Ⅱ的影响。结果:①治疗15d后,治疗组血管紧张素Ⅱ与对照组比较,差异无显著性(P>0.05)。②治疗60天后,治疗组AT-Ⅲ、t-PA较对照组显著升高(P<0.01),PAI-1治疗组低于对照组(P<0.05),FIB治疗组显著低于对照组(P<0.01)。结论:通心络胶囊通过提高体内AT-Ⅲ、t-PA水平,降低FIB、PAI-1和血管紧张素Ⅱ水平来调节体内凝血―纤溶系统平衡。
关键词: 冠心病; 支架置入术; 通心络胶囊; 凝血纤溶; 血管紧张素Ⅱ
Effect of Tongxinluo Capsule on Coagulant and Fibrinolysis System and Angiotension-Ⅱ in Patients with CHD after Intracoronary Stenting
Abstract: Objective: To explore the effect and mechanism of Tongxinluo capsule on coagulant and fibrinolysis system and angiotensionⅡin patients with coronary heart disease after intracoronary stenting. Methods: Fifty-six patients ,accepted intracoronary stenting ,were randomly into 2 groups ,the contro1 group treated with conventional medicine and the treated group treated with conventional medicine plus tongxinluo capsule .The changes of coagulant-fibrinolysis relat……
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