[高血压医学论文] 【关键词】 儿童;轮状病毒;肠炎;利巴韦林;干扰素
[摘要]目的: 观察α-2b干扰素联合利巴韦林治疗轮状病毒肠炎的疗效和不良反应。 方法: 对确诊为轮状病毒肠炎的90例患儿随机分为常规治疗组、利巴韦林组和联合治疗组各30例,疗程5~7d,比较三组患儿止泻时间、退热时间及显效率与总有效率。 结果: 常规组、利巴韦林组、联合治疗组患儿止泻时间分别为(4.76±2.21)d、(4.53±1.84)d、(3.21±0.87)d;退热时间分别为(32.5±7.4)h、(29.3±5.8)h、(22.4±4.6)h,利巴韦林组与常规组比较差异无统计学意义,联合治疗组较常规组和利巴韦林组明显缩短,差异有统计学意义。联合治疗组显效率及总有效率分别为80.0%、96.7%,明显优于常规组和利巴韦林组,差异有统计学意义。 结论: α-2b干扰素治疗小儿轮状病毒性肠炎可明显缩短腹泻及发热时间,提高疗效。
[关键词] 儿童;轮状病毒;肠炎;利巴韦林;干扰素 Clinical study of the effect of IFN-α2b and ribavirin on rotavirus enteritis [Abstract] Objective:To observe the effects of interferonα-2b combined with ribavirin on rotavirus enteritis.Methods:90cases with rotavirus diarrhea were divided into three groups:conventional group(n=30),ribavirin group(n=30)and interferon group(n=30).The duration of us-ing drugs was5~7days.The following indexes were assessed in three groups:the duration of weaning diarrhea and normalized temperature,the percentage of effectiveness of drugs.Results:The duration of weaning diarrhea in conventional group and ribavirin group and interferonα-2b group was(4.76±2.21)d,(4.53±1.84)d,(3.21±0.87)d……
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