【摘要】 目的 探讨血小板激活因子(plateletactivating factor,PAF)拮抗剂E5880在肝脏血流完全阻断下行70%肝切除术中的肝脏保护作用。方法 实验用家兔16只,分成2组。A组:术前无任何预处理,在Pringle法阻断肝脏血流20 min下行70%肝切除;B组:术前用E5880(0.3 mg/kg)行预处理,在Pringle法阻断肝脏血流20 min下行70%肝切除。肝脏再灌注后评估两组动物肝脏功能。结果 B组7 d存活率较A组显著提高(38% vs 0,P<0.05);肝脏再灌注1 h和4 h时,B组血清AST、ALT、mAST、LDH的升高明显被抑制;B组门静脉压和肝脏能荷较A组有明显改善;A、B组肝动脉和门静脉血液中内皮素1水平均明显升高。B组的肝脏白细胞浸润明显减少。结论 术前使用E5880预处理,可以保护在Pringle法阻断肝脏血流20 min下行70%肝切除术后肝脏功能。
【关键词】 血小板激活因子; E5880; 肝切除; 缺血再灌注损伤
【Abstract】 Objective To study the protective effect of plateletactivating factor (PAF) antagonist E5880 on liver in 70% hepatectomy with total hepatic blood flow occlusion. Methods A total of 16 rabbits were equally divided into 2 groups: Group A (rabbits received total hepatic blood flow occlusion for 20 minutes by the Pringle′s maneuver plus 70% hepatectomy without pretreatment) and Group B (rabbits pretreated with PAF antagonist E5880 at 0.3 mg/kg and then underwent total hepatic blood flow occlusion for 20 minutes by Pringle maneuver plus 70% hepatectomy). The remnant liver functions in both groups were evaluat……
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