【摘要】 目的 评价中草药制剂抑毒调平液的抗乙肝病毒效果。 方法 将60例慢性乙型肝炎患者随机分为两组各30例,治疗组口服抑毒调平液治疗,对照组口服安慰剂治疗,疗程3 mo。于治疗前、治疗3 mo末、停药3 mo末进行肝功能、HBVM、HBVDNA定性检测,并进行对比分析。 结果 治疗3 mo末及停药3 mo末,治疗组HBeAg、HBVDNA阴转率均较治疗前有显著升高(P<0.01),而对照组无明显变化(P>0.05);治疗组血清ALT、AST、TBIL水平均较治疗前显著降低(P<0.01);HBeAg、HBVDNA阴转率均显著高于对照组、ALT、AST、TBIL水平均显著低于对照组(P<0.05或0.01)。 结论 抑毒调平液能显著改善慢性乙肝病毒感染者的肝功能,有确切的抗乙肝病毒作用。
【关键词】 乙型肝炎;抑毒调平液;肝功能;HBeAg;HBVDNA;阴转率
【Abstract】 Objective To evaluate the efficacy of Chinese herbal and crude drugs preparationsvirostatic leveling fluid against HB virus on patients infected with hepatitis B virus(HBV). Methods 60 patients with type B hepatitis were randomly divided into treatment group(n=30) took orally virostatic leveling fluid and control group(n=30) did placebo for 3 months. Qualitation detections of liver function, HBVM and HBVDNA were conducted and compared before treatment, at the ends of the 3rd month treatment and of the 3rd discontinuation. Results At the ends of the 3rd month treatment and of the 3rd discontinuation, HbeAg and HBVDNA negative conversion rate heighten……
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