|
白色念珠菌细胞壁β-葡聚糖升白细胞药效学作用的研究 |
[高血压医学论文] 【摘要】 目的 研究白色念珠菌(Candida Albicans)细胞壁不同溶解性的β-葡聚糖(β-glucan)对环磷酰胺(cyclophosphamide,endoxan,cytoxan,CTX)所致小鼠外周血白细胞减少的回升作用。方法 采用CTX所致的小鼠外周血白细胞减少模型,研究白色念珠菌细胞壁β-葡聚糖对小鼠外周血白细胞数的影响。结果 三种溶解性的白色念珠菌细胞壁β-葡聚糖均能升高小鼠外周血白细胞、中性粒细胞和单核细胞数。各组小鼠脾脏指数增加,脾脏、骨髓巨核细胞系增生。不溶性的β-葡聚糖作用更明显。结论 白色念珠菌β-葡聚糖尤其是不溶性β-葡聚糖对CTX所致的白细胞减少有回升作用,是一种很有前途的免疫调节剂。 【关键词】 白色念珠菌;β-葡聚糖;生物学活性;提取分析;免疫药理作用 【Abstract】 Objective To study the pharmacological effect of the basic β-glucan,acidic β-glucan and insoluble β-glucan extracts of Candida albicans on the leukocytopoiesis-promoting in the leukopenia mice.Methods Mice of each group except the untreated control group were administered cyclophosphamide intraperitoneally [100 mg/(kg·d) for three days] to develop leucopenia.The experimental group were administered three kinds of Candida albicans β-glucan intravenously for six days separately.The peripherial leukocytes of all mice were counted before treated CTX,and 1,3,5,7 days after treated CTX.Results Three kinds of Candida albicans β-glucan can increase the numbers of leukocytes,neutrophilic granulocytes and monocytes in the peripheral blood.The spleen ind……
<<<<<全文未完,本文约2790个中文字,未计算英文字母、数字>>>>>
|
|
|
投稿人:gf6h6 |
|
最后编辑:647754 |
高血压医学论文 | 高血压医学论文 |
|